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KMID : 0376219710080010035
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Chonnam Medical Journal
1971 Volume.8 No. 1 p.35 ~ p.39
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Influence of Oxytocin on the renal function of the rabbit
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Abstract
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As it has been reported that oxytocin produces different responses in the renal function of various species, ranging from antidiuresis in the tortoise, to no response in man, and to a marked diuresis in the dog, the action of the hormone on renal function of the rabbit was investigated in this study.
A dose of. 30 mU/kg oxytocin, i. v., elicited slight and transient increases in urine flow, ´renal plasma flow (clearance of PAH), and glomerular filtration rate (clearance of inulin), as well as in the amount of electrolytes excreted. With increasing doses the response became greater. A dose of 100 mU /kg produced highly significant increase in CPAH and significant increase in CPAH, concomitant with increasing tendencies in the excreted amounts of electrolytes and urine flow. The fraction of reabsorbed sodium filtered did not change markedly.
It is thus evident that oxytocin, like in other mammals, influences the renal hemodynamics, increasing the perfusion and glomerular filtration rate, and that the slight diuretic and natriuretic action can be ascribed to this action of oxytocin improving the hemodynamic state.
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